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What is Scleroderma?

Scleroderma (systemic sclerosis or SSc) is a largely misunderstood chronic disease affecting about four people per 10,000 of population.

Scleroderma is an autoimmune disease, a condition in which a person’s immune system turns against itself by producing antibodies that attack its own tissues (i.e. autoantibodies).

This disease is derived from the Greek words “skleros” (hard) and “derma” (skin) and is characterized by progressive skin hardening.

In scleroderma, a protein called collagen is made in larger than normal amounts. This protein is important in many different body functions, including making up skin and blood vessels. The increase in collagen causes thickening of the skin and can cause scars to form in different internal organs including the lungs, esophagus, and kidneys. The organs involved may be different for different patients.

In most cases, scleroderma patients have difficulty with coordinating small movements of the hands and fingers. For example, patients may have trouble doing up buttons and writing.